At the time, 80% of Square Enix staff were made up of former Square employees. Each share of Square's common stock was exchanged for 0.85 shares of Enix's common stock.
was formed in April 2003 from a merger between Square and Enix, with the latter as the surviving company.
Outside of video game publishing and development, it is also in the business of merchandise, arcade facilities, and manga publication under its Gangan Comics brand. is a Japanese multinational holding company, production enterprise and entertainment conglomerate, best known for its Final Fantasy, Dragon Quest, Star Ocean and Kingdom Hearts role-playing video game franchises, among numerous others. A randomized trial is currently not justified for larger tumors or for percutaneous or laparoscopic RFA, since local recurrence rates in these groups are too high to be acceptable for resectable tumors.Square Enix Holdings Co., Ltd. A randomized trial under strict conditions would be justified in this subgroup of patients. Conclusions: Local recurrence rate after open RFA for CRLM ! 3 cm seems to be equivalent to resection. Accumulating evidence suggests that RFA and resection induce profoundly different biological effects, which may influence survival. Local recurrence rates, however, are higher for larger tumors and for the percutaneous and laparoscopic route. For tumors ! 3 cm, local control after open RFA is equivalent to resection. Local recurrence rate after RFA of CRLM is between 1.7 and 66.7%. Results: Local recurrence rate after resection of CRLM is 1.2–10.4%. Methods: An exhaustive review was carried out of papers and abstracts on RFA of colorectal metastases published before July 15, 2008.
The aim of the study was to update and critically review the oncological evidence in favor of and against the use of RFA for resectable CRLM in general and in favor of and against conducting a randomized trial in a selected subgroup of patients. Dig Surg 2008 25:445–460 DOI: 10.1159/000184736 Background: A recent proposal of a randomized trial comparing resection and radiofrequency ablation (RFA) in a selected subgroup of patients with small resectable colorectal liver metastases (CRLM) has initiated a debate on this issue.
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